Antitumor principles derived from Vinca rosea Linn. I. Vincaleukoblastine and leurosine.

نویسندگان

  • I S JOHNSON
  • H F WRIGHT
  • G H SVOBODA
  • J VLANTIS
چکیده

The experimental activity of a new clinically confirmed anti tumor compound, Vincaleukoblastine (C46HssOgN4), (VLB) as the sulfate has been described. Greatest activity was seen against the P-1534 acute lymphocytic leukemia in DBA/~ mice. Late as well as early stages of this leukemia were significantly affected by this compound. No synergistic or additive effects have been observed in combination therapy with other anti tumor compounds. A second indole-indoline alkaloid, leurosine, isomeric with VLB, has also been obtained from V i n c a rosea Linn, with similar demonstrable experimental antitumor activity. Two other alkaloids, vindoline (C25H3202) and catharanthine (C21H2402N2), also obtained from Vinca rosea, were devoid of antitunmr activity singly or in equimolar concentrations, but have been postulated as the biogenetic precursors of VLB and leurosine. Preliminary studies in vitro demonstrated that certain compounds were capable of reversing the growth-inhibitory activity of VLB against human monocytic leukemia cells. These compounds were coenzyme A, aspartic acid, tryptophan, a-ketoglutaric acid, ornithine, citrulline, arginine, and glutamic acid. VLB and leurosine are representatives of a new class of clinically active antitumor compounds which may interfere with the cellular metabolic pathways leading from glutamie acid to urea, and from glutamic acid to the citric acid cycle.

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Biological properties of Vincaleukoblastine, an alkaloid in Vinca rosea Linn, with reference to its antitumor action.

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عنوان ژورنال:
  • Cancer research

دوره 20  شماره 

صفحات  -

تاریخ انتشار 1960